This article explores if and how the entrepreneuring efforts of an endogenous NGO can entrepreneurially empower widow necessity entrepreneurs living in extreme poverty in a rural area of Northern Ghana. In reconceptualizing necessity entrepreneurship as engagement in necessity contexts, three main context specific actions and processes were foregrounded: values-based action focus, upskilling by boundaried choice; and forming, organizing and maintaining symbiotic relationships. Subsequently, the extent to which these actions and processes contributed to empowerment were assessed and explained. Upon outlining how the research contributes to a more comprehensive understanding of entrepreneurship in necessity contexts and broadens our understanding of entrepreneurship, the article ends by discussing the research’s implications and limitations.